I have played a lot of Keno - like A LOT.
I have even seen the probability charts. 1000x on Keno is nearly impossible. Way easier to hit 1000x on Limbo, Chicken or Flip. Plinks 1000x is also really really hard.
My max multi on Keno was 710x once. Hardest setting and 6/6 tiles won.
I usually go for 259x - hardest setting and 4-4 tiles. That wins relatively often.
Good Luck, friend